Journal article
Cryptococcosis-IRIS is associated with lower cryptococcus-specific IFN-γ responses before antiretroviral therapy but not higher T-cell responses during therapy
CC Chang, A Lim, S Omarjee, SM Levitz, BI Gosnell, T Spelman, JH Elliott, WH Carr, MYS Moosa, T Ndung'U, SR Lewin, MA French
Journal of Infectious Diseases | Published : 2013
Abstract
Background. Cryptococcosis-associated immune reconstitution inflammatory syndrome (C-IRIS) may be driven by aberrant T-cell responses against cryptococci. We investigated this in human immunodeficiency virus (HIV)-infected patients with treated cryptococcal meningitis (CM) commencing combination antiretroviral therapy (cART).Methods. Mitogen-and cryptococcal mannoprotein (CMP)-activated (CD25+CD134+) CD4+ T cells and-induced production of interferon-gamma (IFN-γ), IL-10, and CXCL10 were assessed in whole blood cultures in a prospective study of 106 HIV-CM coinfected patients.Results. Patients with paradoxical C-IRIS (n = 27), compared with patients with no neurological deterioration (no ND; ..
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Awarded by National Institutes of Health
Funding Acknowledgements
This work was supported by the REACH Initiative (Research and Education in HIV/AIDS for Resource Poor Countries) and Pfizer Neuroscience research grant. C. C. C. was supported by an Australian Commonwealth Government Postgraduate Award 2009 and the Australian National Health and Medical Research Council (NHMRC) Postgraduate Scholarship 2010-2012. S. M. L. was supported by National Institutes of Health grant AI025780. T. N. was supported in part by an international Early Career Scientist grant from the Howard Hughes Medical Institute and by the South African Department of Science and Technology/National Research Foundation Research Chairs Initiative. S. R. L. is a NHMRC practitioner fellow. M. A. F. was supported by NHMRC grant 510448.